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KMID : 1134819970260030475
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Journal of the Korean Society of Food Science and Nutrition
1997 Volume.26 No. 3 p.475 ~ p.479
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Effect of Hormone Replacement Therapy on the Changes of Pyridinoline from Bone and Cartilage Collagen of Ovariectomized Rats
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Kim Mi-Hyang
Yu Ri-Na
Ha Bae-Jin
Kim Sang-Ae
Koh Jin-Bog
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Abstract
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A decrease in the circulating levels of estrogen, occuring as a consequence of post menopausal decline or from surgical ovariectomy, results in an accelerated loss of bone. Estrogen has been shown to stimulate lysyl oxidase activity, and the treatment with estrogen increased the pyridinium content of cortical bone. A trivalent mature cross-links of collagen fibrils named pyridinoline, which is especially abundant in collagen of cartilage and bone, markedly increases with growth in humans and rats. The main aim of this study was to examine the increased bone loss caused by ovariectomy through monitoring the concentrations of the collagen and the pyridinium crosslinks of collagen, pyridinoline. The ovariectomized rats, 4 weeks old, were divided at random into two or three groups of 5. Ovariectomies were carried out on both of the saline-treated group(OVX(NH)) and the estrogen-treated group(OVX(H)) using the dorsal approach and sham operations were performed on the sham-operated group(sham). They were maintained under identical conditions for 4 or 8 weeks and were allowed free access to food and water. It was observed that there was no significant difference between the control group and the sham-operated group, however, the control group had a higher content of collagen than the saline?treated group after 4 weeks and 8 weeks. Based on these results, it is supposed that estrogen can enhance collagen synthesis and affects the pyridinoline formation in collagen fibrils through stimulating lysyl oxidase activity.
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KEYWORD
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ovariectomized rat, collagen, pyridinoline, lysyl oxidase
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